THE STUDY OF LIPID SPECTRUM AND MARKERS OF VASCULAR INFLAMMATION IN PATIENTS WITH STABLE ANGINA PECTORIS WITH DIABETES MELLITUS
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Abstract
Annotation. In recent decades, the role of a chronic inflammatory process in the development of cardiovascular complications in patients with coronary artery disease and diabetes has been actively discussed. Target. study of markers of the vascular inflammatory process in patients with coronary artery disease in combination with type 2 diabetes. Identify a set of laboratory parameters that can become predictors of cardiovascular complications. Materials and methods. We examined 69 patients aged 60.3±9.8 years with coronary artery disease, stable exertional angina. Patients are divided into 2 groups. Group 1 - patients with IHD (n=30), Group 2 - IHD with type 2 diabetes (n=39). Results. The study of laboratory parameters of blood serum was carried out against the background of standard therapy before and after 12±2.4 months of observation. Initially, in the 2nd group of patients, a significant excess of the level of atherogenic parameters of the lipid profile (total cholesterol, VLDL, TG) and markers of inflammation (highly sensitive C-reactive protein, fibrinorgen ) was revealed compared to the 1st group. In IHD patients with DM in the 2nd group, more numerous and highly significant relationships were registered between atherogenic lipid fractions (LDL, TG), inflammatory markers (highly sensitive C-reactive protein , fibrinogen), endothelial dysfunction parameters (brachial artery diameter), glycated hemoglobin. The analysis of the results demonstrated the absence of positive significant dynamics of the lipid spectrum, the preservation of a prolonged response to the activation of the inflammatory reaction, the indicator of which was C-reactive protein, fibrinogen, and the presence of endothelial dysfunction in both groups of patients. The results of the study indicate the persistence of a sluggish inflammatory process in the endothelium, which is a provoking factor in the destabilization of the atherosclerotic process, both in the 1st and 2nd groups of patients. Conclusion. The increased risk of atherothrombosis in both groups requires more stringent control of the effectiveness of the therapy.
Key words : ischemic heart disease, diabetes mellitus, inflammatory markers, endothelial dysfunction.
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References
Aleksandrov A.A. Diabetes mellitus: a disease of "exploding" plaques. Consilium medicine . 2001;1(10):464–468.
Lukyanchikov BC, Zvereva I.V. Pathogenesis and prevention of vascular complications in metabolic syndrome and type 2 diabetes mellitus. Russian medical journal. 2008;4: 14–20.
Titov V.N. Commonality of atherosclerosis and inflammation: specificity of atherosclerosis as an inflammatory process. Russian medical journal. 2009;5: 44–49.
Serik S.A., Stepanova S.V., Volkov V.I. Inflammatory activation in stable and unstable angina // Ukr . therapist. magazine - 2002. - No. 4. - S. 38-43.
Altman R. Risk factors in coronary atherosclerosis athero- inflammation: the meeting point // Thrombosis J. - 2003. - Vol. 1, No. 1. - P. 4-14.
Aukrust P., Ueland T., Lien E. et al. Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy // Amer. J. Cardiology. - 1999. - Vol. 83, No. 3. - P. 376-382.
Deswal A., Petersen NJ, Feldman AM et al. Cytokines and with ytokine receptors in advanced heart failure: an analysis of the cytokine database from the vesnarinone trial (VEST) // Circulation. - 2001. - Vol. 103, No. 16. - P. 2055-2059.
Ikonomidis I., Andreotti F., Economou E. et al. Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin // Circulation. - 1999. - Vol. 100, No. 8. - P. 793-798.
Mann DL Inflammatory mediators and the failing heart: past, present, and the foreseeable future // Circ. Res. - 2002. - Vol. 91, No. 11. - P. 988-998.
Ono K., Matsumori A., Shioi T. et al. Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling // Circulation. - 1998. - Vol. 98, No. 2. - P. 149-156.
Opal SM, DePalo VA Anti-Inflammatory with ytokines // Chest. - 2000. - Vol. 117, No. 4. - P. 1162-1172.
Orus J., Roig E., Perez-Villa F. et al. Prognostic value of serum cytokines in patients with congestive heart failure // J. Heart. lung transplant . - 2000. - Vol . 19, No. 5. - P. 419-425.
Parissis JT, Adamopoulos S., Karas SM et al. An overview of inflammatory cytokines cascade in chronic heart failure // Hellenic J. Cardiology. - 2002. - No. 43. - P. 18-28.
Ridker PM, Rifai N., Pfeffer M. et al. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction // Circulation. - 2000. - Vol. 101, No. 18. - P. 2149-2153.
Robbins M., Topol EJ Inflammation in acute coronary syndromes // Cleveland Clinic. J. Med . - 2002. - Vol . 69 ( Suppl . 2). - P. 130-142.
Elmuradovna, J.E. (2021). Qarshi qal’asi arxitekturasi, tashkil topishi, o‘tmishi va buguni. O'rta Evropa ilmiy byulleteni , 18 , 247-252.
Elmuradovna, J. E., Turdimurodovich, M. I., & Zuyadullayevich, Z. U. (2020). Modern tourist requirements in samarkand. International Journal of Scientific and Technology Research, 9(4), 1538-1540.
Modern tourist requirements in samarkand.
Elmuradovna, J. E. (2021). The Architecture of Karshi Castle, The Establishment, The Past and the Present. Middle European Scientific Bulletin, 18, 247-252.
The Architecture of Karshi Castle, The Establishment, The Past and the Present.